Ayurueda, an eternal system of medicine, is accepted as a holistic system of medicine due to its multidimensional approaches and unique fundamental concepts for the prevention and promotion of health. It advocates number of fundamental concepts regarding prevention and promotion of health as well as cure of diseases. Such as- the concept of shatpadartha, the concept of panchamahabhuta, the concept of six rasa, the concept of karyakaranavada, the concept of dosha, dhatu-upadhatu and mala, the concept of chaturvidha ayu, the concept of arogya and raga etc. which are endowed with scientific temperament having strong philosophical base and universal acceptance. That's why it is specific from other systems of medicine as any science or discipline can grow and survive upon the valid fundamental principles. The concept of shatpadartha (samanya, vishesha, guna, dravya, karma & samavaya) is one of the important concepts in clinical practices to maintain the dhatusamya (equilibrium state of body tissue). Guna (quality or property) is one of the shatpadartha which is the cause for the efficacy of any dravya (medicine) and has inseparable concomitance (samavaya-sambandha) with dravya. Charaka Samhita advocates four types of guna i.e. Sartha guna (shabda, sparsha, rupa, rasa & gandha), Gurvadi guna (properties beginning with guru etc.), Atma guna (buddhi, sukha, dukha, ichchha, dvesha and prayatna) and Paradi guna (beginning with para etc.). Out of these four types of guna, the Gurvadi guna have a crucial role in the clinical practice either it is the preventive medicine or curative medicine. Every substance either it is dietary substance or medicine, possess these Gurvadi guna and even our activities or life style also produce the effects similar to Gurvadi guna in the form of lightness, heaviness, coldness, hotness etc. So the proper use of every substance keeping in mind the Gurvadi guna present over there, we can prevent many more diseases but at the same time improper use of the same leads to the manifestation of different ailments. Hence it becomes essential to discuss the concept of Gurvadi guna and this research paper is meant to discuss the concept at the length to make it more explainable and applied.