Uncompolicated urinary tract infection (UTI) is associated with multiplication of organisms in the urinary tract, and is defined by the presence of more than loo,obo organisms per ml in a midstream sample of urine (MSU). Such infections are much more common in women, and cause considerable morbidity, and account for 1.2 % of all consultations in general practice. Community surveys suggest that the prevalence of urinary tract infection in women is about 3% at the age of 20, increasing by about 1% in each subsequent decade. About 5o% of women suffer symptoms of urinary tract infections. Due to surface fimbriae adhere to surface receptors on the urolithelium E coli appear well adapted to invade the urinary tract lead haematogenous infections. Particularly in women most are ascending infections colonize at periurethral zone with pathogenic faecal organisms. Colonisation is also facilitated by tissue damage from previous UTI by infections of the genital tract or perineal skin, by inadequate perineal hygiene and possibly by use of disinfectants, deodorants, certain toilet preparations and urethral trauma. Instrumentation of the bladder readily introduces organisms. Urine is a good culture medium, and multiplication of organisms introduced into the bladder depends on the size of the inoculum and virulence of the bacteria. The herbal regime named Goksuradi Guggulu AFI Sarangdhara Samhita, developed and formulated on the scientific basis by Indian Medicines Pharmacoceutical corporation Ltd. Almora Uttaranchal was obtained for trial, which exerts overall therapeutic activity with safety in urinary tract infections. This ayurvediya drug establishes the synergism of various herbo-constituents of nature, as in 1 gram the components are the decoction of Gokslzru 1.708 gram,Suddha guggulu 427 mg, Trikatu, Trif Musta each 61 mg. This drug was prescribed in the dose of 1-3gram daily with Ushir Kvath. A study of total 4o patients of uncomplicated Urinary Tract Infection randomly selected from the OPD of Clinical Research Unit, Safdarjung Hospital, New Delhi was carried out with Goksuradi Guggulu along with pathyapathya. The trial drug corrected the abnormalities, prevented the process of colonization, acted as an alkalizer, as diuresis and simultaneously toning the renal system. These drugs by virtue of its phytoconstituents, provides certain bio-molecules and electrolytes and also reversed elevated leucocytes count and urea level towards the normal. (J. Ethnopharmacol (2003 Apr.; 85 (2-3) 257-6o) Phytoconstituents of the trial drug exerted potent antimicrobial effect against various gram +ve and gram —ye bacteria viz.E coli, Staphylococcum Streptococci, Pseudomonas, Klebisiella and Proteus sps. etc.responsible for UTIs. Constituents elicited positive diuresis; and helped in eliminating microbes. Gokshuradi guggulu also acted as alkalizer, normalizes the urinary pH. The result provides relief in UTIs' probably by inhibiting COX and LOX enzymes. The herbo mineral combination is synergism corrects abnormalities and prevents recurrence. (J.Res. Ayu. Sid. VOL. XIV, 3-4, P98-114) and possesses marked nephroprotection against nephrotoxins induced injury. Besides, these drugs in combination, promptly relieve the symptoms of urinary disorders, act as potent diuretic and improve the tone in urinary bladder atony. ( Management of Mutrasmari by three Ayurvedic drugs —(1987),PVVI). The result of the trial was encouraging and fortifying the above claim.