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Journal of Ayurveda

A Peer Reviewed Research Publication of
National Institute of Ayurveda, Jaipur

TABLE OF CONTENT

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

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Pharmaceutical Study

V Gayathri Devi*, Anitha John*, K Gopakumar**

Physico-Chemical Identification Of Vasaguducyadi Kvatha Curna — An Ayurvedic Formulation

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS - Vasaguducyadi, Standardisation, Panduroga, Home remedies
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ABSTRACT

Vasaguducyadi kvatha curna is commonly used in Ayurveda for the treatment of Pandu, Raktapita, Kamala etc. It is prepared with eight authentic ingredients by the Clinical Research Unit of Regional Research Institute, Trivandrum as described in Ashtangahridaya and was analysed from the standardisation point of view. A detailed chemical analysis of the preparation was carried out to lay down the pharmacopoeia! standards. The physico-chemical characteristics of the drug like loss on drying at no'C, a.1.1 value, acid insoluble ash, water soluble ash, solubility in water and alcohol, fibre content, tannin content etc. were determined. Thin Layer Chromatographic (TLC) profile of the petroleum ether and alcohol extracts of the curna and its eight ingredients were taken. High Performance Thin Layer Chromatographic (11PTI.C) finger print of the alcohol extract of the curna was also taken. Chromatographic studies were carried out to compare the Fcvalues of the chemical constituents of the curna and its ingredients. Moreover the drug was tested for arsenic and heavy metals and they were found to be below permissible/ detectable limit. This shows that the drug is not affected by environmental pollution and pesticides. The drug was tested for fungal and bacterial contamination and was found to be absent. Ultra-Violet (UV) and Infra-Red (IR) spectra of the curna were taken and these spectra are characteristic for a particular compound/ extract. All the data obtained from physico-chemical tests, 111 values of TLC, HPTLC, UV and IR data may be used as pharmacopoeial standards for Vasaguducyadi kvatha curna.

Clinical Studies

*Dr Akhlesh Bhargava, **Dr Manoj Adlakha, ***Prof. H. K. Kushwaha

A Clinical Evaluation of Madhukadi and Jatyadi taila along with standard Kshara-Sutra therapy in the Management of Bhagandara (Fistula-in-ano)

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS - Fistula, madhukadit jatyadi, unit cutting time
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ABSTRACT

In kshara-sutra therapy the cutting and healing of fistulous track takes simultaneously. In some cases it has been observed that the healing status of track was not satisfactory. In that situations the cutting of track further delayed and it takes more time to completetion the treatment of Fistula-in-ano with standard Kshara-sutra. An oil with wound healing property may useful in reducing the overall treatment in Fistula-in-atm. Keeping this view and to avoid complication and promote the better healing, Madhukadi taila and iTatyadi Taila had been used along with Ksharasutra. It was found that Madhukadi Taila is more competent and effective than Jatyadi taila in the management of Bhagandara (Fistula-in-ano).

Clinical Studies

*Dr. Raakhi Mehra, **Dr. Renu Makhiza, ***Dr. Neera Vyas

Study Of The Goksuradi Guggulu In Uncomplicated, Urinary Tract Infection In Female Patients

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS - Goksuradi Guggulu, Uncomplicated urinary infection, female, Mutrakricchra
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ABSTRACT

Uncompolicated urinary tract infection (UTI) is associated with multiplication of organisms in the urinary tract, and is defined by the presence of more than loo,obo organisms per ml in a midstream sample of urine (MSU). Such infections are much more common in women, and cause considerable morbidity, and account for 1.2 % of all consultations in general practice. Community surveys suggest that the prevalence of urinary tract infection in women is about 3% at the age of 20, increasing by about 1% in each subsequent decade. About 5o% of women suffer symptoms of urinary tract infections. Due to surface fimbriae adhere to surface receptors on the urolithelium E coli appear well adapted to invade the urinary tract lead haematogenous infections. Particularly in women most are ascending infections colonize at periurethral zone with pathogenic faecal organisms. Colonisation is also facilitated by tissue damage from previous UTI by infections of the genital tract or perineal skin, by inadequate perineal hygiene and possibly by use of disinfectants, deodorants, certain toilet preparations and urethral trauma. Instrumentation of the bladder readily introduces organisms. Urine is a good culture medium, and multiplication of organisms introduced into the bladder depends on the size of the inoculum and virulence of the bacteria. The herbal regime named Goksuradi Guggulu AFI Sarangdhara Samhita, developed and formulated on the scientific basis by Indian Medicines Pharmacoceutical corporation Ltd. Almora Uttaranchal was obtained for trial, which exerts overall therapeutic activity with safety in urinary tract infections. This ayurvediya drug establishes the synergism of various herbo-constituents of nature, as in 1 gram the components are the decoction of Gokslzru 1.708 gram,Suddha guggulu 427 mg, Trikatu, Trif Musta each 61 mg. This drug was prescribed in the dose of 1-3gram daily with Ushir Kvath. A study of total 4o patients of uncomplicated Urinary Tract Infection randomly selected from the OPD of Clinical Research Unit, Safdarjung Hospital, New Delhi was carried out with Goksuradi Guggulu along with pathyapathya. The trial drug corrected the abnormalities, prevented the process of colonization, acted as an alkalizer, as diuresis and simultaneously toning the renal system. These drugs by virtue of its phytoconstituents, provides certain bio-molecules and electrolytes and also reversed elevated leucocytes count and urea level towards the normal. (J. Ethnopharmacol (2003 Apr.; 85 (2-3) 257-6o) Phytoconstituents of the trial drug exerted potent antimicrobial effect against various gram +ve and gram —ye bacteria viz.E coli, Staphylococcum Streptococci, Pseudomonas, Klebisiella and Proteus sps. etc.responsible for UTIs. Constituents elicited positive diuresis; and helped in eliminating microbes. Gokshuradi guggulu also acted as alkalizer, normalizes the urinary pH. The result provides relief in UTIs' probably by inhibiting COX and LOX enzymes. The herbo mineral combination is synergism corrects abnormalities and prevents recurrence. (J.Res. Ayu. Sid. VOL. XIV, 3-4, P98-114) and possesses marked nephroprotection against nephrotoxins induced injury. Besides, these drugs in combination, promptly relieve the symptoms of urinary disorders, act as potent diuretic and improve the tone in urinary bladder atony. ( Management of Mutrasmari by three Ayurvedic drugs —(1987),PVVI). The result of the trial was encouraging and fortifying the above claim.

Clinical Studies

*Dr. O. P. Sharma, **Dr. Bharti Bandil

Clinical Evaluation of Malla Sindoor Yashti Madhu Churna In The Management of Tam.ak Shwasa (W.s.r. to Bronchial Asthma)

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS - Tamak Shwasa, Allergic, Asthma, Malla Sindoor, yashti Madhu churna, Peenas, kasa, Dyspnoea, Wheezing, Trachea-bronchial tree.
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ABSTRACT

Tamak Shwasa is a krichra sadhya or yapya kind of disease caused by vitiated Vata and Kapha doshas. It is a disease of Pranvaha, tJdakvaha and Annavaha Shrotas. Tamak shwasa can be compared with Bronchial Asthma of Modern Medicine on the basis of the similarity in its causes and clinical symptoms. In this clinical trial we have used a combination of Malla sindoor and yashti madhu Churna in Tamak Shwasa in 20 patients. The improvement in the status of patients was assessed an the grades of various variables compared between pre trial and post trial values. There was a great relief found in all the symptoms in all the patients after the trial. Statistically the medicine was found to be highly significant in treating 25 symptoms, Significant in treating 6 symptoms and was found non significant in the shaman of a single symptom. The average relief in the severity of the symptoms was 60.57%. The Average relief found in the patients was 62.66%.The Laboratory Investigations before and after the trial indicates that there was a marked lowering in the easinaphil counts, T.E.C. and E.S.R. in all the patients after the trial, which is indicating towards the effectiveness of the medicine in Tamak shwasa.

Clinical Studies

*Dr. P. C. Mangal, **Dr. Atul Bhardwaj, ***Dr. Mahendra Kumar Sharma

Clinical evaluation of Wyoshadi Vati' and Chitraka Haritki Awleha' in management of Pratishyaya' with special reference to Allergic Rhinitis

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS - Allergic rhinitis, Pratishyaya, Vyosadi Vati, Cliitraka haritki Awleha
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ABSTRACT

Pratishyaya is a Vata-Kaphaja Predominant Tridoshaja disease. The disease is mast vividly described among all 'Nasa Rogas' but the description seems to be scattered at various places. There is descriptive mention of this disease with regard to aetiopathogenesis, classification, symptomatology, complication and management. This reflects that ancient Ayurvedic galaxy was well versed with the concept of Pratishyaya. Aachatya Stishruta and Vagbhatta has mentioned five types of `Pratishyaya'. These five different type of Pratishyaya reflects different types of rhinitis. For the present study Allergic rhinits has be scrutinized and a sincere Endeavour has been made to evaluate the clinical effects of 'Vyosadi Vati' and 'Chitraka Haritki Awleha' in management of `Pratishyaya' with special reference to Allergic rhinitis. Allergic rhinitis, a benign but chronic disease of the upper airways is increasingly recognized as an important Public health problem. These two formulations are mentioned in Ayurvedic classical texts and a time tested management of Pratishyaya. In this present research work 26 patients of Allergic rhinitis were studied by randomly dividing them into three groups. Patients of first group were given 'Vyosadi Vati' only, the next group was given `Chit•aka Haritaki AwaIeha' and the third group of patients were given both the formulations simultaneously. The duration of treatment was 21 days in all the groups with weekly evaluation of the patients. The analysis based on subjective and objective improvement, Haematological and radiological indices revealed that all three regimen are found to be effective while the group treated with the combination of the two formulations reflected best improvement and significant relief to the patients.

Literary Reviews

*Dr. Sangram Mishra, **Dr. Santosh Mane ***Dr. Mahes Vyas, ****Dr. R.R. Dwivedi

Guna Samkhya' a Critical Study

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS - Guna, Vaishesika, Nyaya, Samkhya
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ABSTRACT

The concept of Guna is peculiarity of Ayurveda. The literary meaning denotes string thread, a cord, a garland etc. Though the very science keeps similarity'of views with Samkhya, Vaishesikas Darsana Sastras in many regards, the concept of Guna in Ayurveda is molded in such a way that it becomes useful in clinical practice. Dravya and Guna in spite of having independent identity are supplementary to each other. Sole importance cannot be attributed to any of them. The numbers of Gunas are described in every Sastras according to their utility. The Samkhya also varies in every text, but all are having two main divisions, i.e. Adhyatmic or Adhibhautic. Some new Gunas are also described in different context, which can be compared within Gurvadi Gunas. So the detail descriptions of Guna Samkhyas are highlighted in the paper.

Survey Study

Kishor Patvardhan*, Sangeeta Gehlot**, Girish Singh***, H.C.S. Rathore****

Graduate level Ayurveda Education: Relevance of Curriculum and Teaching methodology

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS -
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ABSTRACT

The present study was planned to evaluate the relevance of graduate level Ayurvedic education as perceived by the students and teachers. The study is based on the subjective perceptions of a sample of students and teachers drawn from various Ayurvedic educational institutions spread all over India in the form of their responses to a semi-structured questionnaire designed for the purpose. However, education in Ayurveda has been a cause of concern in recent years. Though, the Council has implemented various educational norms and regulations to ensure minimum standards of education, there has been a mushroom growth of sub-standard colleges causing erosion to the standards of education and harm to medical training and practice (National Policy on ISM&H, 2002).

Literary Reviews

*Dr. Sudipt Rath, **Dr. S. Bhaskaran, ***Prof. Mahesh Chandra Sharma

WHOLE HERBS vis-a-vis EXTRACTS

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS -
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ABSTRACT

Traditionally herbal materials were used after crude pharmaceutical processing like powder, decoction, paste, etc. But with advancements in chemistry, medicinal plant materials are being processed into extracts, fractionates, isolates, etc. and are preferred in the industry. But, very little has been done to see the pharmacological difference between the crudely processed whole herb and its chemically purified products. Also, any process adds cost to the product, thus what is the cost benefit ratio of such endeavours. Some recent studies indicate that extracts, etc. are not necessarily better substitutes of the traditionally dosages, rather in some cases they are indeed inferior. The authors have compared effects of powder and various extracts of the roots of Chlorophyturn boriuilianam S & F and found that the traditionally used powder form is superior to its extracts and fractionates. Of course, quality assurance demands chemical compound based identification and assay, but before putting extracts into day to day clinical practice due diligence should be exercised to find out if these are therapeutically and economically better than the traditional dosages.

Literary Reviews

Dr. Sangram Mishra, Dr. Santosh Mane, Dr. Mahes Vyas, Prof. R.R. Dwivedi

Guna Samkhya' a Critical Study

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS -
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ABSTRACT

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Literary Reviews

Dr. Hemanta Kumar Panigrahi*

Medicinal maggots (Krimi chikitsa): An Ancient remedy for some contemporary Afflictions

2009   |   April-June   |   VOLUME - III   |   ISSUE - 2

KEYWORDS - MDT (Maggot debridement therapy), Krimi, Arbuda
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ABSTRACT

Medicinal maggots (Krimi) are also used medically. The medicinal use of live organisms, such as maggots, leeches, bee venom, or even microorganisms, is sometimes referred to as Biotherapy. The art of magotification is also entirely an Indian method. It is again Shusruta who first successfully described the feasible method of magotification in treating Arbuda(tumour). Shusruta is attributed the glory of discovering the feasible way of magotification. Shusruta in Cikitsa sthan IP chapter verses 37 in the treatment of "Arbuda chikitsa" described about maggotification. Medicinal maggots have three actions: By Dibride (clean) wounds, by dissolving the dead or, necrotic, infected tissue,by disinfecting the wound by killing bacteria, by stimulating wound healing.

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