ISSN:2582-7693

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Journal of Ayurveda

A Peer Reviewed Research Publication of
National Institute of Ayurveda, Jaipur

TABLE OF CONTENT

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

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Editoral Forum

*Vaidya Pawankumar Godatwar

Essential Bio-Statistics: Clinical Research Designs Part-II

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Study design, RCT, Case-control, Cohort, CONSORT, ICI-I, USFDA
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ABSTRACT

A clinical trial is an experiment conducted with patients as subjects. On one hand, carefully planned and well-executed RCTs give us the best estimates of treatment effect while on the other hand, trials that lack in proper methodology cause over or underestimation of treatment effect. With these factors in mind, efforts have been made to improve the quality of reporting of RCTs. The Consolidated Standards of Reporting Trials (CONSORT) statement provides a 22-item checklist and subject flow chart for the transparent reporting of RCTs. This statement has been adopted as a framework for the reporting of RCTs by hundreds of medical journals. Use of the CONSORT statement has definitely improved the quality of RCT reports. US-FDA and ICH provide a significant guidance in the appropriate design of clinical studies. Clinical studies can be basically classified as Randomized and Non-Randomized studies each having their sub classifications. RCT is the golden standard of clinical study design.

Editoral Forum

*Dr. Parimi Suresh, **Dr. Vinaya Kumari, ***Dr. Kamalesh Kumar Sharma

Heavy Metal Toxicity

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Ayurveda, Inorganics, Herbals, Rasaoushadhis, Toxicity, Negative propaganda
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ABSTRACT

Ayurveda, the Indian Traditional system of Medicine, has tapped very successfully all the natural resources viz; plant, animal and mineral kingdoms. The emergence of highly therapeutic potential agents-the rasaoushadhis (inorganics/ elements) have not only changed the entire system i.e initial herbal orientation but also brought a revolutionary resurgence especially post samhita period. The western system too at one point of time has depended upon certain inroganics including arsenic, mercury and others for curing ailments. But in recent past the vested interests in the western system are engaged in negative propaganda about the Ayurvedic preparations specifically inorganics. If this trend is allowed to continue the day will come that they will prove even herbal medicines are also toxic and unsafe besides present publicity over contamination of heavy metals. K

Pharmacological Study

*Dr. Renuka Joshi, **Dr. Anand Kumar Choudhary, ***Pradeep Kumar Prajapati, ****Dr. B Ravishankar

Safety study of Yashad Bhasma

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Bhasma, Safety, Yashada, Zinc
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ABSTRACT

Herbo-Metallo-Mineral medicinal preparations called Bhasma are unique to the Ayurvedic and Siddha systems of Indian Traditional Medicine. These Bhasma preparations are being used since ancient times and are very effective and potent dosage form in minute doses. However, there is a lack of scientific analytical studies carried out on Bhasmas in general and Safety and toxicity studies in particular. Yasada Bhasma is a unique preparation of zinc. Yasada Bhasrna has been used successfully by Ayurvedic practitioners for the treatment of various diseases such as diabetes and age-related eye diseases since ages. This work presents a comprehensive safety study of Yashada Bhasma in three dosage forms on various parameters such as Hematological, Biochemical, Histo-pathological etc. The Safety profile of Yashada Bhasma shows it to be quite safe.

Standardization

*Dr. Galib, **Dr. A.C. Kar, ***Dr. A. Narayana

Standardization of bhasma - Need of the Hour.

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS -
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ABSTRACT

Ayurveda, the most popular healthcare system since ancient times, touched to new dimensions after having incorporated with the knowledge of Rasaushadhies from 8th A.D. onwards. Since then the metals and minerals were used abundantly in various dosage forms and in due course of time Rasa Shastra became an integral part of Ayurveda. Regarding these Rasa preparations, Acharya Nagarjuna was of the opinion that, these are highly potent drugs. In one word, it can be said that, Rasa preparations are the strength of Ayurveda. The use of metallic preparations in healthcare is a unique characteristic feature of Ayurveda & Siddha systems of medicine. The doses of these preparations are very small and the shelf life is very Lang and duration of treatment is also short. These features have importance in treatment. There are a number of metals / minerals like Iron, Cupper, Gold, Silver, Mercury, Sulpher, Arsenic, Lead and Tin Etc. have been mentioned in Ayurveduic classics for therapeutic purposes. The bhasma preparations are crucial as it involves many processing techniques involving nanotechnology. Different types of processing techniques like, Pounding, Grinding, Boiling, Heating, Dipping in different liquids etc. have been explained in ancient texts, which have their own scientific background, The sequence of these processes may change from metal to metal. All these processes are to be studied properly in preparing standard classical ayurvedic drugs for Quality Assurance. The paper discuses about the classical concepts and few modern parameters to be adopted in Bhasma Standardization.

Pharmaceutical Study

*Dr Amita Jhunjhunwala, **Prof L. K. Dwivedi

Comparative Pharmaceutical study of Abhraka Bhasma with Madhumehari Kwath Putit Abhraka Bhasma

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Abhraka bhasma, Shodhana, Marana, Pharmaceutical study
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ABSTRACT

Various methods of preparation of Abhraka bhasma are described in the Rasa texts ranging from puta 1 to moo. For the present study after Shodhana and Dhanyabhrakikarana, Io puti Abhraka bhasma was prepared by trituration and puta with Arka ksheera for 7 times and Vata jata kwatha for three times. Thus prepared Abhraka bhasma was divided into two parts. One part is further processed by Trihiration & puta with Kadali kanda swarasa for 7 times and Vata jata kwatha for 3 times. The procedure of A.F.I. followed is merely an extension of Io puti Marana process of various Rasa texts. Thus one sample of 20 puti AB-1 was prepared according to standard procedure. The other sample of m puti Abhraka bhasma was processed using Madhumehari churna kwatha as a triturating media upto 20 puta. Overall 4gm or approximately 2% increment was found in the standard sample of AB where as the MC kwath bhavita AB showsthe increase of 103 gms which was approximately 5o% more from the starting material.

Literary Reviews

*Dr. K. Shankar Rao

Indian Medicine: A Global Domain Of Medicinal Mineralogy Mineralo-Herbal Drugs

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Dhatuvada, Dehavada, Shodhana, Marana, Amritikarana.
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ABSTRACT

The study of ancient Indian Medicine literature indicates that the use of Minerals, Gems and Metals as medicines have begun in 7th century A.D. and before this treatment diseases was done mainly with herbal medicines, worships and prayers of chnating mantras etc.. Nagrjuna is considered to be the father of Indian alchemy. The Minerals and Metals used for the preparation of Ayurvedic drugs are Pravala, Shankha, Pearls, Diamond, Gold, Silver, Copper, Lead, Tin, Zinc and some alloys etc.. A large number of processes have been described for the preparation of minerals and mineralo-herbal medicines in the Ayurvedic text but no specific process control has been discussed. In the present paper it has been endeavoured to understand the basic principles and concepts on minerals and mineralo-herbal drugs and their medicinal importance. In this paper the processing details of Yashada bhasma has been described. All Such literary evidence shows that the Indian Medicine is a global authority in the field of therapeutic use of minerals and mineralo-herbal drugs.

Clinical Studies

*Dr. Sharma Chander Shekhar, **Dr. Mehra B. L., ***Chaudhary Vijay

A Clinical Study to evaluate the efficacy of Meetha Neem (Murraya Koenigii) in management of amlapitta with special reference to Non Ulcer Dyspepsia.

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Amlapitta, Non ulcer dyspepsia, Meetha Neem, Haritaki, Gastric juice.
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ABSTRACT

Amlapitta is one of the burning problem of our society. Erroneous food habits and day by day increasing stress and strain due to changing life style are the important factors behind the increasing incidence of this disorder. Vitiation of Agni is the main pathophysiological derangement in Amlapitta. There is an increase in Arida Guna of Pachakapitta and this Amlibhoota Pitta does not perform its main digestive function. Due to the derangement of functions of Agni, a metabolic disequilibrium is produced leading to the production of Area. Ultimately the undigested food gets fermented to Shukta form and results in Amlapitta. Indiscriminate use of several drugs like steroids etc. also predispose to this disorder. In the present clinical study, clinically diagnosed Amlapitta patients were given Meetha Neem Patra Churna in the dose of 5 gm twice a day for a duration of 45 days after doing Kostha Shuddhi with Haritaki Churna. Patients were thoroughly assessed on various subjective and objective parameters every fortnightly. After 45 days of therapy, a significant improvement in various clinical features of Amlapitta was observed. Fasting gastric juice samples also showed a significant reduction in free and total acid contents. Thus Meetha Neema along with Haritaki has a definite role in the management of Arnlapitta.

Clinical Studies

*Dr. Gyan Prakash Sharma, **Dr. 0. P. Sharma, ***Dr. R. S. Sharma

A Clinical Study of Matra Basti & Kati Basti In The Manegement of Gridhrasi W.S.R.To Sciatica

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Naanatmaj vyadhi, Sakthikshepnigrah, Kati basti, SLR, Dashvidha Pareeksha
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ABSTRACT

Gridhrasi (Sciatica) is Vataj Nanaatmaj vyadhi. Gridhrasi, also presents with a clear picture of shifting pain in lower limbs radiating from sphik, kati, prishtha and affecting uru, janu, jangha and pada in order. 'sakthiutkshepanigraha' is mentioned as a cardinal sign by Sushrut and Vagbhat. But certain other symptoms such as stambha, toda, sphurana, ruk etc. are also found in some other disease.Diseases like urustambha, khalli kalaykhanja, vatakantaka can make confusion with Gridhrasi. Inspity of the spine's excellent form and function, back pain is a national, personal and clinical problem: national because it is experienced by most of the population at some time and is a drain on the nation's resources, personal because it can remain a major unresolved dilemma. Group A (Matra Basti) & GroupB (Kati Basti) with Dashmool Oil was decided to manage the Gridhrasi. The Result was excellent in both Group. Haematological values were also improved.

Clinical Studies

*Dr. Bharti,**Dr. Renu Makhija,***Dr. Adarsh Kumar,****Dr. S.C.Mahapatra,*****Dr. Mahader Prasad

Shirodhara -Pilot Observations In Anidra (Insomnia)

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - insomnia, shirodhara, stress, anxiety, sleep
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ABSTRACT

Stressors like too much noise, light, heat, cold, caffeine, jet-lag, excitement, anxiety of pain, change in sleeping hours, anxiety disorders or depression cause insomnia. A vicious circle develops between sleeplessness and fear for trying to go to sleep. When insomnia is a chronic condition drugs are less effective. Ayurvedic treatment (Shirodhara) is advisable in such conditions. In simple stress situations (without a real psychiatric disorder) short term insomnia may develop and Shirodhara may be useful as it alleviates stress and gives passive relaxation. 20 Patients of Anidra (Insomnia) due to headache, Anxiety Neurosis and other psychological disorders were selected and administered shirodhara for 7 days. Symptomatic improvement in induction and duration of sleep was observed after treatment. The patients also felt more calm and relaxed. Their anxiety levels also lowered down.

Experimental Studies

*Dr. Vishnu Dutt Sharma, **Dr. Anuradha Sharma, ***Prof. H. K. Kushwah

An Indigenous approach to manage the Chronic Osteomyelitis (A pilot study)

2008   |   July-September   |   VOLUME - II   |   ISSUE - 3

KEYWORDS - Chronic osteomyelitis, Sequestrum, Pain, Swelling, Discharge, Indigenous Kwath, latex of Arka, Ingredients.
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ABSTRACT

This pilot study evaluates the efficacy of an ayurvedic combination of indigenous kwath and latex of Calotropis procera to remove sequestrum from chronic osteomyelitis sinus, which is very undesirable & obscurant object for the patients. 15 patients suffering from chronic osteomyelitis were taken for this study and divided in three groups of 5 patients in each group. Comparative study was done between three groups by giving indigenous kwath in A group, latex of Arka (Madar) in B group and combination of two ingredients in C group. Results suggested that there was marked relief in removing sequestrum in those patients who were treated with combination of herbal ingredients.

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