Problem of allergy particularly respiratory allergies are increasing throughout the globe at the alarming rate. Each year number of alleru sufferers increases by five percent. It is proposed that allergic reactions are the price we are paying for our life style. The Shirishadi Compound in the present study on statistical analysis of morbidity features has shown highly significant results in sneezing, dyspnoea, itching (nasal / eye), wheezing and cough and significant results in nasal discharge, loss of smell, nasal of obstniction, headache, hoarseness of voice, fever and throat inflammation. The follow up study depicts the sustained effect of the therapy. Appreciative improvement was observed in I-Ib%, TLC, ESR, while PEFR. (Peak expiratory flow rate), Eosinophil count, TEC and IgE show marked reduction. The research drug has been found to have anti-allergic, bronchodilator, anti-stress, adaptogenic, anti-tussive, mucolytic, antioxidant and immunomodulatory effect.
Testes and sukravahasrotas are sensitive to temperature. The scrotal contents arc kept 2 to 4DC below the temperature of the abdominal cavity. Anatomic features of the scrotum and testes provide the regulation of testicular temperature. Effects such as decrease in testicular size, degeneration of cells in the seminiferous epithelium, decrease in sperm out put, impaired sperm quality with a reduction in the percentage of viable, motile and morphologically normal spermatozoa, ultra structural and functional changes in the epididymis and decreased fertility has been reported with increased scrotal temperature. Varicacele probably interferes with the cooling mechanism or increases catecholamine concentration. Varicocele may be of etiologic importance in as much as one third of all male infertility. It is formed by the dilation, elongation and tortousity of the veins of the pampiniform plexus in the spermatic cord. This paper presents clinical evaluation of Varicocele as an etiological factor.
Dr. Mita Kotecha*, Dr. K. Shankar Rao**
Clinical Evaluation of Haridra & Chitrak in the Management of Medoroga (Obesity)
Obesity is a metabolic disorder, generally occuring in affluent societies, because of imbalance between energy intake and energy expenditure. It is associated with mortality and predisposes to the development of fatal diseases viz. Diabetes, Hypertension, MI, etc. Hence there is an immense need to explore an effective medication for this disorder.
This clinical study was conducted on Haridra (Curcuma longa) and Chitrak (Plumbago zeylanica).The selected drugs have potent lekhana action and belong to Lekhana group of herbs as described in Charaka samhita (Ch.Su,4).Lekhana is a process of emaciation, drying up or desiccation of all excess Dosha, Dhatu and Mala (Dathan Su.Su.4o:50 Bhavprakash Pu.Kh.6:224) .Thus Lekhana drugs ought to have potent anti obesity action. Both drugs were found effective against cardinal as well as general symptoms of Medovriddhi,though efficacy of Chitrak was found to be better than Haridra.
Prof. M. Srinivasului*, Prof Mahesh Chandra Sharma**
A study on combined effect of Shaala, Mundi & Naadihingu on Hyperlipoprotienamia
The term Hyperlipoproteinaemia (HLP) is a condition of lipoprotein in circulation.. To transport water immiscible lipids into predominantly aqueous environment of the blood the lipid particles are stabilized with a coat of amphiphilic compound, phospholipids and proteins - the resulting particles are lipoproteins. According to ayurveda, this HLP condition is of Medo dhatu vikara. Due to defect in Dhatuparinama of Medodhatu, two medodhatu vikaras are resultants. sthayimedodhatu i.e. sthoulya due to increase of fat in fat depots and another is asthayi medo dhatuvikara (HLP) due to increase of fat in circulation. Due to over consumption of fatty food and deficient physical exercise, Defect in a metabolic pathway because of an enzyme missing or not functioning properly (due to defective dhatwagni), Mandagni due to genetical causes or swabhavahetus or any secondary causative disorder, ultimately leading to agnimandyata of medodhatu. In search to fulfill that aim, we found these 3 drugs namely saala, nadihingu, mundi. Out of which two are resins with better action at GIT and at liver and another is an established drug for antioxidative, hepato protective property. Mundi(Sparanthus Indica) panchangas Rasakriya (Ghana satwa) has been done as per the procedure laid down in sarangadhara samhita (bhaishaja kalpana vidhi) - Saala(Shorea robsta) niryasa collected and powdered. Nadihingu(gardenia gummifera) whole plant along with niryasa has been taken dried in shadow, powdered and administered in the form of 5oomg. capsule . The compound has been found highly effective on all factors of MP, within a short period starting from 15 days to one month. Within one month maximum effect was noticed and the drug was continued for one more month next followed up without drug from 6 months to 1 year, where it's action was sustained. No side effects were noticed either during the period of drug administration or during the following period.
Dr. K. J. Malagi*, Dr. M. S. Kamath*, Dr. B. S. S. Rao***, Dr. P. Uma Devi****
Role of Swedana Therapy against a transplantable mouse tumour — An Experimental Study
The validity of hyperthermia was known in India since the vedic times Swedana (Sudation Therapy) has been practiced extensively for different types of diseases. The beneficial effect of hyperthermia in the treatment of cancer was reported as far back as the time of Hipocrates about 400 B.C. Hyperthermia in the tempeprature range of 41°C to 45°C has been known to show tumouricidal effect both in experimental and clinical studies. The present experimental study was aimed to study the effect of Swedana Therapy against a transplantable mouse tumour BI6F1 melanoma. Swedana treatment was given locally for 2 and 4 minutes and tumour regression was observed. Both the treatment groups showed more than 65% complete response (CR) without any systemic toxicity. In view of the present experimental findings it is very clear that localized Swedana therapy in a temperature range of 60°C to 7ocC for period of 2 to 4 minutes is sufficient for the elimination of localized mouse solid tumour. However the potential effect of Swedana therapy has to be tested against several tumour models in experimental animals before embarking any clinical studies.
*Dr. A. K. Choudhary, **Dr. Ankit Gupta, ***Dr. B. Patgiri,****Dr. S. De, ****Dr. P. K. Prajapati
Standardization of Vasa Avaleha prepared by Swarasa & Kwatha
Vasa, due to its habitat grows through out India, is an easily available drug in almost all the seasons. Easy availability of any drug gains popularity amongst physician as well as pharmaceuticals. And this is the reason why almost every Kalpana of Vasa is found described in the Ayurvedic text. The word Quality with reference to a dosage form is comprehensive and refers to characteristics like the potency, uniformity, purity, pharmacological action, stability etc The parameters like Organoleptic, physico-chemical, stability etc plays key role by which the quality of any dosage form can be determined. In the present study Vasa Avaleha was prepared using Swarasa and Kwatha then analyzed on parameters like organoleptic, physico-chemical which includes pH, total solid content, sp. gravity T.L.0 etc. The results show that water soluble extract was more in Vasa Avaleha (K) where as methanol soluble in Vasa Avaleha (S). T.L.C. studies show that vasicine was present in both the samples of Avaleha while Vasicinone was only in Vasa Avaleha(S).
Charaka has stated the importance of takra & has designated a complete chapter to elaborate the qualities of Takra& Mastu in Takravarga. Whey or mastu contains the Whey protein. Whey or mastu is an invariable ingredient in all the members of takra varga. The ingredients of Takravarga find therapeutic application as a dravadravya in a spectrum of preparations like Takrarista, Takrasava, mastvasava Etc. Whey proteins are well known for their high nutritional value and versatile functional properties in food products. Nutritional and functional characteristics of whey proteins are related to the structure and biological functions of these proteins. During recent decades, interest has grown in the nutritional efficacy of whey proteins in infant formula and in dietetic and health foods, using either native or predigested proteins. The indications appear to be of a broad spectrum, an attempt to provide scientific research data to the attributed pharmacological activities is made in this review article.
Statistics is defined as science of figures i.e. science of collecting, summarizing, presenting, analyzing and interpreting the data. Broadly statistics can be divided into descriptive statistics to describe the data and inferential statistics which allows us to draw conclusions.
We need statistics in the planning stage of protocol for collection of data (sample size, unbiased sample, randomisation etc.), then we describe our results in a summarized form using terms such as mean, standard deviation, standard error and very often presentation of data to others using various graphs. Next we need it for hypothesis testing to draw some conclusion from a research project. And lastly we need to devote a paragraph on statistical methods used when we send our data for publication in various journals. Thus statistics has become an absolute necessity in medical research. The present article tells about the importance of statistics in research, helps in understanding the principles of selecting a statistical test based on the objectives of the study, tells the use and application of some of the commonly used statistical tests and methods, teaches how to prepare a checklist to assess the statistical aspects of a research paper and recognize and minimize common statistical errors. Finally it helps in Understanding factors influencing sample size and its calculation.
Dr. Mukund Sabnis *
BIOMARKERS Todays need in Ayurvedic research
2007 | April-June | VOLUME - I | ISSUE - 2
KEYWORDS - Biomarkers, Ayurveda, Chemical Composition, Biological Activity, Herbal
Ayurvedic drugs are multi targeted medicines which exhibit diverse effect on the body. Many of the Ayurvedic herbs show multidimensional activity. Biomarkers serve to elaborate the diverse action of the herbs and herbo mineral compounds. There are three approaches to natural product-based drug discovery: screening of crude extracts; screening of pre-fractionated extracts; screening of pure compounds . In the past decade there has been a paradigm shift from single-target drugs to multi-target drugs . Preparation of highly standardized herbal products with respect to chemical composition and biological activity is complicated due to the myriad range of chemicals. Use of proper bio markers is indicated in Ayurved . These bio markers can be used as Yukti praman, which are known to explore etiology, diagnosis and prognosis of the disease. This review highlights applications of Biomarkers in developing pharmacodynamics of Ayurvedic procedures and herbal compounds along with quality control of herbal drugs and extracts.