From stone-age to space age food pattern of people has undergone numerous changes.These changes have been always for the better aspect of life. Most of the vikara are deeply rooted in underprivileged dietary habits like Ajirne Bhojana, Akale Bhojana, Akale Anshana, Virudha Bhojana, Atimatrasy Amla, lavana, Katu Rasa Sevanam etc; improper life style like Vegvidharana, Divaswapa, Ratri Jagrana etc; and Mansik Bhavas like Chinta, shoka, bhaya, krodha etc. and amlapitta is one of them. Keeping this in mind it was decided to carry out clinical trial on 30 patients presenting classical signs and symptoms of Amlapitta. The patients were selected irrespective of their age, sex, religion etc. Selected patients were divided into Group A and Group B respectively and treated by Kushmanda Khanda prepared using ghrita (KKG) and Kushmanda Khanda prepared without using Ghrita (KKW). In group A and B there were 15 patients in each. The results were analyzed on the basis of improvement in cardinal, associated signs and symptoms. Statistically analysis between Group A and Group B for the observation parameters Avipaka, Aruchi, Utkelesh, Tikta-Amlodgara, Gaurava, Klama, Chhardi and Shirhshula found no significant changes and it showed that the relief % of both Groups were closely similar. But in observation parameter of Daha the difference value of group A is higher than group B. It shows that group A has higher relief as compare to group B.